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Molecular analysis of neurons from patients with Focal Cortical Dysplasia Type II identified dysregulation of several genes associated with neuronal migration during neurogenesis and embryonic neural progenitor cell differentiation, which is a key factor that underlies development of the malformed cortical tissue within the brains of these patients that underlies their epileptic activity (Majolo et al., 2019)

The chronic-tonic regime produces signals the pulsed regime cannot

Sustained benefits suggest successful tissue remodeling