How to know if your microdose is working Three signals that your current dose is effective: Reduced appetite without nausea : Youre eating less because youre genuinely satisfied, not because you feel sick
Nuts Rich in protein, fiber and healthy fats, nuts such as almonds, walnuts and pistachios may naturally increase GLP-1 Healthy fats Avocados, nuts, and olive oil are rich in monounsaturated and polyunsaturated fats, which stimulate the release of GLP-1
weight loss (Phase 2/3 peak) | ~15% | ~22% | ~24% | | FDA Status | Approved (Wegovy, Ozempic) | Approved (Zepbound, Mounjaro) | Phase 3 (2026) | | Dosing frequency | Weekly | Weekly | Weekly | The additional glucagon receptor agonism is believed to be responsible for retatrutide's greater metabolic rate increase and enhanced fat oxidation compared to dual agonists
Cardiovascular outcome trials for tirzepatide are ongoing, but the favorable effects on intermediate markers suggest probable long-term cardiovascular benefit