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A vial that looks perfectly clear can contain denatured protein fragments if bacteriostatic water was added too quickly, if the peptide warmed above 8C during mixing, or if non-sterile air entered the vial during draw
Pulmonary administration enables high local drug concentration, rapid action, and bypasses the first-pass effect, making enzyme-responsive micro-/nanoparticles an attractive strategy for site-specific treatment in the inflamed lung 78
These symptoms should improve with continued use, not worsen indefinitely
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