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"Systematic review and meta-analysis of the efficacy of N-acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease." Ann Palliat Med

Studies have shown that resveratrol (0.1 M) and curcumin (1 ppm) supplementation increases insulin secretion and improves -cell function by inhibiting the gene expression of phosphodiesterase (Pde3b, Pde8a and Pde10a) through activation of the cAMP signaling pathway in human (HP62) and mouse pancreatic -cells ( 4.2 Terpenes and terpenoids from plants and mushrooms in antidiabetic therapy: biosynthesis, mechanisms and therapeutic potential Terpenes represent a large and highly diverse group of secondary metabolites, primarily lipophilic, encompassing around 30,000 compounds

James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O et al

Med 384 , 9891002 (2021)