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Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]
Maintains a youthful glow and healthier and fresher skin
For clinicians, it opens the door to consider these medications not only for metabolic health but potentially for reducing alcohol-related harm
The positive impact of GLP-1RA therapy on lipids is an important contributor to these outcomes
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