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Thus, the combination of DUB-resistant and proteasome-targeting ubiquitin linkages promotes the degradation of deubiquitylation-protected substrates, underscoring the role of branched ubiquitin chains in shifting the ubiquitin conjugation/deconjugation equilibrium
There is some limited preclinical data that it could impact tissues involved in reproduction, but direct, reliable evidence showing a connection to improved human fertility is missing at this time
this rules out the non-specific effects of confounders in HFD-fed mice
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