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Still, its not clear whether B12 supplementation can reduce the risk of heart disease directly (13)
Exp Gerontol 95
Here are some factors that can affect how quickly you notice results: Severity of Deficiency: Individuals with mild deficiencies may experience quick relief, but those with very low B12 levels might require several doses before a noticeable difference occurs
Short-term (weeks to months), the refrigerator is fine
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