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The anchoring trials are STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

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The various epithelial cells along the length of the renal tubular filtration systems have distinct functions that are dictated by the unique organization of their basolateral and apical membranes

Semaglutide and tirzepatide have also displayed a mean 6069% 10-years relative risk reduction of T2D development