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It affects regulated BBB transport and receptor systems that are essential for normal BBB function, as well as decrease the functional activity of ion transporters ( + , K + , 2Cl cotransporter and Na + , K + -ATPase on BECs and inhibits P-gp activity in the CNS ( + /organic cation antiporter system is involved in blood-to-brain nicotine transport across BBB endothelial cells TR-BBB13 (Tega et al., 2018

Modern drug screens are highly selective and chemically specific

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The results showed that rats treated with DSIP recovered motor skills faster than untreated rats, even though the size of the brain damage wasnt significantly reduced