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Long-acting GLP-1 receptor agonists have little effect on gastric emptying due to the development of tolerance to GLP-1 effects mediated by changes in parasympathetic tone (Wettergren et al, 1998
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Scientists have long recognised the potential benefits of transdermal drug delivery, including improved patient compliance, steady drug release, and avoidance of gastrointestinal degradation and first-pass metabolism
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