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The strains work together to generate postbiotic metabolites, including butyrate and a protein called P9, that stimulate intestinal L cells to secrete glucagon-like peptide-1

The authors note that the current publication represents an early proof-of-concept analysis and that larger, longer-term studies will be needed to confirm the durability of the reproductive benefits observed

GLP-1 medications such as Ozempic are now widely marketed to help treat obesity, but there has also been a rise in companies selling unauthorised supplements or treatments

Mazdutide overall appears to achieve superior weight loss, in shorter periods of times compared to GLP1R agonists