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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

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Comparing the oxygen required for the oxidation of different substrates to generate ATP, the oxygen efficiency of glucose is generally considered to be more favourable than that of acetyl-CoA, which is more similar to fatty acids