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if neurological involvement is present, maintenance is every two months Oral therapy is generally not appropriate where absorption is impaired (e.g., pernicious anaemia), as adequate levels cannot be reliably achieved Because B12 is water-soluble and any excess beyond hepatic storage capacity is excreted in the urine, it has a low toxicity profile
The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again
Most formulations of methylcobalamin injection contain benzyl alcohol as a preservative
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