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Most patients experience this symptom during dose escalation phases, when the medication is new to their system
Genetic variants affecting GIP or GLP-1 receptor function might identify patients most likely to benefit from dual agonism
Both substances affect blood glucose regulation and gastrointestinal function, creating potential risks including hypoglycemia, worsened side effects, and impaired treatment outcomes
Details of the method are available in Schroder et al
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