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Angiopoietin-2 secretion by endothelial cell exosomes
Knockout of sestrins, or at least impairment of their leucine-binding ability, could make mTORC1 activity insensitive to leucine stimulation
These functions include augmentation of dendritic arborization and synaptogenesis, neurogenesis, facilitation of hippocampal long-term potentiation (LTP) and calcium signaling (hypothesized building blocks of memory consolidation), angiogenesis and facilitation of cerebral blood flow and cerebro protection
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