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Recent studies have shown that patients on high-dose semaglutide can lose an average of 15% to 20% of their body weight, a level previously achievable only with bariatric surgery
In addition, short-term symptomatic benefits must be rigorously weighed against the risk of long-term dysbiosis caused by antibiotics 175
Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
Studies were screened based on title and abstract for relevance
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