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The approval creates a new treatment option for people struggling with obesity and weight-related health conditions, while wider decisions on NHS access will determine how quickly the medicine becomes available to patients across Northern Ireland and the rest of the UK.

By working closely with their patients and other specialists, healthcare providers can effectively manage any potential side effects and help patients achieve their health goals

Sinomenine is an active alkaloid from Sinomenium acutum , and its derivative facilitates interactions between nuclear receptor coactivator 4 (NCOA4) and FTH1, accelerating Fe 2+ release and ultimately promoting ferroptosis in colon cancer cells (Zhu et al., 2024)

Strimvelis for treating severe combined immunodeficiency caused by adenosine deaminase deficiency: an evidence review group perspective of a NICE highly specialised technology evaluation