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Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: evidence from preclinical studies
This bioactive molecule originates from catechin or epicatechin units which in turn constitute procyanidins that are highly abundant in the French maritime pine bark extract Pycnogenol (see sections 1.2.2 Pharmacodynamics, 4.1 Absorption into plasma/serum and concentration profiles, 5 Biodistribution, and 6.1 Pre-systemic metabolism: role of gut microbiota)
Most users do not report immediate effects
Phenotypic screening is the pragmatic alternative: apply the peptide to a relevant cell system and measure broad outputs, transcriptome by RNA-seq, proteome, or metabolic and viability panels, without presupposing a target
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