Folic acid is a synthetic, unnatural form of folate, which nonetheless is capable of being absorbed, transported, taken up by cells, and converted (by the action of the enzyme dihydrofolate reductase) to the active forms of folate
Olivotto I, Udelson JE, Pieroni M, Rapezzi C (2023) Genetic causes of heart failure with preserved ejection fraction: emerging pharmacological treatments
Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)
On the other hand, addition of 30 mM GSSG, an oxidized form of GSH which has no antioxidant properties but is intrinsically acidic, resulted in a reduction in biofilm viability comparable to or greater than 30 mM GSH at intrinsic pH levels (Figure 5B)