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Ozempic was approved by the FDA in 2017 to treat people with Type 2 diabetes who risk serious health consequences without medication
A novel peptide mimetic, FN075, was found to promote endogenous -syn aggregation in vivo , and injection of FN075 into the substantia nigra of rats resulted in motor dysfunction and loss of dopaminergic neurons, suggesting that -syn aggregation is associated with the development of PD (Olsen et al., 2019)
These modifications significantly inhibited the cellular uptake of both dopamine- or ibuprofen-coupled nanocarriers compared to the unmodified control groups (Fig
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