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The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

And the dose-dependent effects were clear: 4 mg, 8 mg, and 12 mg doses all produced escalating weight loss, with the highest dose delivering the most dramatic results

In dermal fibroblasts, GHK-Cu reduces TNF-alpha-induced secretion of IL-6, a major positive regulator of fibrinogen synthesis and inflammatory responses

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