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Immunoblot of UGDH in the indicated isogenic cell lines transduced with a doxycycline-inducible shGFP or a sh UGDH construct doxycycline treatment (doxy, 1 g/mL) for 24 h
Levocarnitine supplementation could theoretically enhance this approach by ensuring that the increased fat mobilization from exercise and caloric restriction is efficiently processed in the mitochondria
J Cell Biol 2009
Another patient with FTO rs9939609 risk alleles and lower natural carnitine transporter activity might benefit significantly from targeted L-carnitine support
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