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Important safety considerations include the risk of hypoglycemia when tirzepatide is used in combination with insulin or sulfonylureas (requiring dose adjustments of these medications), potential thyroid C-cell tumor risk (contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and the possibility of acute pancreatitis
Research comparing mice treated with GLP-1 medications versus those on calorie restriction with similar weight loss showed the GLP-1 group had substantially greater reductions in liver fat 19
In the SUSTAIN trial, 52% of patients receiving semaglutide experienc ed gastrointestinal side effects, compared with 35% in the placebo group
