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Newer agents tend to produce greater glucose lowering and weight loss, but may also cause more gastrointestinal symptoms during dose escalation

Although glucagon typically raises blood sugar, in the presence of GLP-1 and GIP, the response becomes more balanced, leading to: increased energy expenditure enhanced fat oxidation greater metabolic burn at rest reduction in liver fat prevention of metabolic slowdown during weight loss This combination makes retatrutide particularly effective for individuals who typically plateau on GLP-1 drugs due to metabolic adaptation

Diabetologia 61, 722726

These peptides can help individuals achieve fitness goals by increasing growth hormone secretion and improving body composition