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This paradigm shift has important implications for treatment durationjust as patients with hypertension or diabetes require ongoing medication management, individuals with obesity may need continuous pharmacological support to maintain weight loss and associated health benefits
Over time, this accelerates cartilage wear and contributes to osteoarthritis progression
However, tirzepatide slows gastric emptying, which could theoretically alter oral methotrexate absorption
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In patients that are not yet impaired in insulin signaling, nasal application of insulin may accelerate insulin resistance
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