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Human studies have mainly described pharmacokinetics, safety, and tolerability, rather than demonstrating strong clinical effectiveness
The primary endpoints were changes in body weight (BW) and HbA1c (HbA1c) from baseline to 3 months
Patients with pre-existing diabetic retinopathy should be aware that rapid improvements in blood glucose control may be associated with temporary worsening of retinopathy, particularly with semaglutide
This changed significantly with the approval of Wegovy for heart disease in patients with obesity, as this allows Medicare to make patients eligible for the drug
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