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Increased VAT could expose the liver to excessive fatty acids and glycerol via portal lipid flux, and then cause increased hepatic glucose and triglyceride production and decreased insulin clearance, thus leading to hepatic IR [35, 39, 40]

But it said there was a complex relationship between mental illness and the conditions GLP-1 drugs treat, and also a possibility that weight loss itself could be associated with suicidal thoughts

This long-term efficacy has led medical organizations to view GLP-1 therapy as a viable chronic treatment option, similar to how we approach blood pressure or cholesterol management

Even mid-range doses such as 5mg will nearly double to 180