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It is unknown whether TRULICITY causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of dulaglutide-induced rodent thyroid C-cell tumors has not been determined [see Warnings and Precautions (5.1), and Nonclinical Toxicology (13.1)]
doi:10.1007/s10534-014-9736-5
In line with this phenotype, liver microarray analyses consistently show dramatic intrinsic suppression of lipogenic genes in GCLM KO mice 17,39
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