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By 5 mg, the sustained signal approaches the peak produced by a large meal. In diabetes trials, every dose improved insulin sensitivity while reducing the amount of insulin needed. GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal
Arthralgia, joint and muscle pain, presents one of the most common symptoms occurring in 10% to 15% of patients
10.1080/00039890109604483 Arch
The BNF suggests the use of oral tablets to replace any dietary deficiency in B12 but does not recommend them for treating Pernicious Anaemia that should be treated with injections
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