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The advantage of our measurement of the Glutathione Index (GSH/GSSG) is therefore that it shows changes in GR activity not only due to higher/lower GR gene activity but also due to the absence of the reaction cofactor NADP
& Ismail, N
This is due to the elevated cellular vulnerability to oxidative stress and reactive oxygen species (Gawryluk et al., 2011)
Some people notice subtle shifts, perhaps slightly easier sleep onset or marginally improved morning alertness, but many notice nothing at all
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