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The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade
Other reported effects include water retention, joint stiffness, mild flu-like symptoms, and temporary increases in blood glucose levels
Kupffer cells (KCs), which are the largest population of resident macrophages in the liver, are the first innate immune cells and protect the liver from infections
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