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therefore, drugs targeting EPHB1, PI3K/AKT, and Bcl-2/Bcl-xL, which are involved in the apoptosis resistance pathway, have been developed 28

Keywords : Sorafenib, Cardiotoxicity, Ferroptosis inhibitor, FSP1, GPX4, KLF11 Sorafenib is a tyrosine kinase inhibitor that potently blocks tyrosine kinase targets, including vascular endothelial growth factor (VEGF) receptors, platelet-derived growth factor (PDGF) receptors, and v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) [1-3]