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118 Furthermore, cerebral hyperinsulinemia is associated with diminished clearance of A peptides due to the competitive inhibition of insulin-degrading enzyme, a metalloprotease responsible for degrading both insulin and A, which preferentially binds insulin over A under hyperinsulinemic conditions
This may contribute to a reduction in the risk of chronic diseases
The entire book, chapter by chapter, can be found here: Osteoarthritis (OA) is not just a wear-and-tear disease
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