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MS in Family Practice Medically reviewed by Dr
The 2020 meta-analysis found a statistically significant reduction in body weight and fat mass, with the best results at doses around 2 grams per day
3 It works by: Stimulating insulin release when blood sugar is high (glucose-dependent, so it doesnt cause insulin release when blood sugar is normal) Reducing glucagon secretion (glucagon is a hormone that raises blood sugar) Slowing stomach emptying, which reduces blood sugar spikes after meals Acting on appetite centres in the brain to reduce hunger Why the combination works When both medications are together, theyre addressing multiple aspects of blood sugar control: Metformin focuses on the glucose our liver produces (fasting blood sugar) Mounjaro focuses on the glucose spikes after meals and helps with weight loss Together, they improve insulin sensitivity in different ways Significantly, because Mounjaro only stimulates insulin release when blood glucose is elevated, adding it to metformin doesnt substantially increase the risk of hypoglycaemia (low blood glucose)
Basically, it makes your workout better
