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In addition to lowering blood glucose, reducing food intake, and delaying gastric emptying (20, 28, 29), it also reduces body mass (2, 3), reduces liver sugar output, and increases insulin sensitization (22)
Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai
It may also improve insulin sensitivity and reduce blood sugar levels, Dr
This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
