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A diverse pipeline of potential therapies for DKD exists, including incretin agonists, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase stimulators and agents that target inflammatory pathways such as Janus kinase/Janus kinase 2 inhibitors and IL-6 monoclonal antibodies
The cell bodies of vagal sensory neurons are clustered in the nodose ganglion, and recent transcriptomic profiling based on single-cell RNA sequencing analysis has identified more than a dozen genetically distinct subclasses [48, 49]
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