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Lancet 374 , 3947 (2009)
J Invest Dermatol 136:19551960 Guitera P, Pellacani G, Crotty KA, Scolyer RA, Li LX, Bassoli S, Vinceti M, Rabinovitz H, Longo C, Menzies SW (2010) The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face
Because copper itself has a narrow physiological range, protocols involving repeated or high-frequency application in animal models often include copper-load monitoring alongside the primary remodeling endpoints, to rule out confounding from excess trace-mineral exposure rather than peptide-specific signaling
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