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3.8 Xenobiotics and neurotoxicity 3.8.1 Background Xenobiotics are chemical substances foreign to the human body, commonly found in pharmaceuticals, food additives, pesticides and environmental pollutantsmaking exposure unavoidable (Jin et al., 2023)
Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
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