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All serious adverse events (AEs) and the following AEs irrespective of seriousness were collected: AEs leading to premature treatment discontinuation, AEs of special interest, and AEs related to COVID-19

Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]