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This localized hypoxia (lack of oxygen) forces cells to switch to anaerobic energy production, generating excessive lactic acid and causing rapid, severe muscle fatigue even after minimal physical exertion

Notably, completed and ongoing studies such as NCT06475586, NCT06937060, NCT06588296, and NCT06864026 are investigating semaglutide in patients with PsO and comorbid metabolic conditions, or tirzepatide (in PsA settings), assessing dermatologic outcomes and inflammatory or metabolic markers (78, 79)

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