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Cytopenias: In 645 patients with B-cell malignancies who received IMBRUVICA as a single agent, grade 3 or 4 neutropenia occurred in 23% of patients, grade 3 or 4 thrombocytopenia in 8%, and grade 3 or 4 anemia in 2.8%, based on laboratory measurements
Dosing tiers: Fasted administration is standard protocol
Mishandling opened vials can lead to contamination or decreased effectiveness
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