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Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA
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Ann Rev Pharm Toxicol
Signs of an Allergic Reaction: If the aches are accompanied by a rash, hives, swelling of the face or tongue, or difficulty breathing
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