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The honest caveat: nearly all mechanistic data comes from cell cultures or animal models

[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

While the spheroids treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere majorly consisted of living cells, the spheroids treated with NP4 in a 1% O 2 atmosphere consisted of dead cells (Fig

Therefore, researchers have been investigating various botanical drugs that could be used as an alternative for UF