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Adipose tissue remodeling and obesity
A 2023 analysis of 340 patients using semaglutide with 16:8 fasting (16-hour fast, 8-hour eating window) found that medication users achieved their fasting goals on 2.3 days per week more consistently than fasting-only controls
Similar findings emerged from the STEP weight management trials, where heart rate elevations of comparable magnitude were documented
Interestingly, while GSH declines in fibrosis, cysteine levels are elevated, suggesting that reduced GSH is primarily due to enzyme dysfunction rather than substrate deficiency [123]
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