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Increase the dose incrementally beyond the initial planned maximum, or extend the observation window before concluding the peptide is ineffective

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IGF-1 is a primary mediator of growth hormone (GH), with growth-promoting effects on most cells and tissues including skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung [1]

Of clinical significance is the recent observation that blocking perilipin-2 (Plin2) activity in mice leads to inhibition of diet-induced obesity