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Published 2019 Oct 10
We found that the RNA-recognition motifs RRM1 and RRM2 of SFPQ are required for its binding to R-loop-containing chromatin in U-2 OS cells
AAV production for Chac2 silencing To construct AAV vectors for the specific silencing of Chac2 in mouse BM neutrophils, we first selected target sequences for mouse Chac2 mRNA using the application program from Dharmacon siDESIGN center ( The specific shRNA sequence 5-CTACAGAACTACGACAGTCAT-3 was designed
After GlyNAC treatment, GSH concentrations in muscle and red blood cells increased but decreased markers for oxidative stress, while no improvements were seen in the young adult group or the placebo-treated older adult group
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