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Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Naveed Sattar and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Indeed, the European multicenter study coordinated by Graham reports that, whereas basal hyperhomocysteinemia only shows an additive effect with hypercholesterolemia, it has a synergistic effect with both hypertension and smoking on the incidence of atherosclerotic vascular disease (Graham et al, 1997)
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