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10.1104/pp.102.4.1193 109 MayoS.CominelliE.SparvoliF.Gonzlez-LpezO.Rodrguez-GonzlezA.GutirrezS.et al

Henry cautions layering it with strong actives such as benzoyl peroxide and retinoids and recommends spacing them out (use vitamin C in the morning and retinol at night, for example)

People with cardiovascular, renal or thyroid disease, those taking chronic medication or those who have had previous reactions to supplements