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In high-intensity exercise, this metabolic shift is hypothesized to increase energetic efficiency, reduce lactate accumulation, delay fatigue, and accelerate post-exercise recovery, which helps explain its attraction in elite sport ( Also, persistent uncertainty regarding long-term safety, limited high-quality human data in athletes, and its status as a banned substance continue to raise ethical and regulatory concerns ( Human physical performance: mechanistic rationale vs

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Biochemical and Biophysical Research Communications, 588, 140146