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Food and Drug Administration, but is expected to be submitted for approval this year, Azar noted

Some patients report: Aching in the knees, hips, shoulders, hands, or ankles Generalized stiffness or body aches Muscle soreness or weakness Pain that appears after a dose increase Changes in an existing arthritis condition Discomfort after becoming more physically active A symptom beginning after someone starts tirzepatide may suggest a possible connection, but timing alone cannot prove that the medication caused it

Incretin-based therapies for type 2 diabetes include inhibitors of the enzyme dipeptidyl peptidase-4 and GLP-1 agonists

This ends in low B12 levels